Psoral Clinical test result

Psoral cream usage clinical test result

Authors:
Dr. M. Burshtein, doctoral candidate, Ashkelon, North Israel.
G.Oded. master, pharmacist. Bio Anti Aging Laboratory, herzliya, Israel.
Milovanova e.V., physician-homeopath, c. Pervomaisk, Ukraine.

 

Every doctor is familiarized with difficulties in dermatological diseases treatment. Often, the patients have already tried many treatment methods. However they go to the homeopath expecting our help anyway. We strongly believe that when there are manifestations of dermatological diseases the whole body is sick. Then we try to heal the skin from the inside. But, what we can offer in the case of an unbearable itching that does not let us live? Several patients have used corticosteroid creams for decades. Will homeopathic medicine pass this "barrier"? Over one year ago we had the opportunity to test patients with skin diseases (such as psoriasis) with an homeopathic treatment. We used “Psoral” cream containing Pinus palustris (production of Dr. M. Burstein LTD, Ashkelon, Israel).

The Israeli company Dr. M. Burstein LTD which has spent many years of research in cosmetic healing field, created Psoral cream. It was used successfully for skin affected by diseases such as psoriasis, eczema, neurodermatitis, pruritus, atopic dermatitis etc.

Dr. Burstein was born in Russia. After the WW2 his family moved to Peru and settled at the capital, Lima. After graduating from college, Dr. Burstein worked as a dermatologist. Later, he became Dean of the faculty of medicine at the University of Lima. At the same time, he founded a scientific and research laboratory dedicated to dermatology problems. Specialists of different countries were invited to this laboratory.

Dr. Burstein has been interested in the therapeutic action of pine oil, the resin obtained from Pinus palustris pine, which grows in Peru. Scientific studies were conducted for two decades. As a result they created the formula of the psoriasis treatment cream Psoral intended for psoriasis affected skin, eczema, neurodermatitis, pruritus, for atopic dermatitis, exudative catarrhal diathesis and others. The main active components of "Psoral” cream is based on pine oil. This active component is turpentine. The “Psoral” cream is elaborated with other components such as vitamins and Dead Sea water. Turpentine is the resinous substance that is secreted into the lesion of coniferous trees. It is stored in resin ducts, which traverse the trunk of the pine tree.

Solidified on the trunk surface, turpentine protects the wood against penetration of beetles, fungi and others, and also "cure" injuries of the tree. Turpentine is a mixture of oil, aromatic oil resin and grinding. The aromatic oil is obtained by the distillation method, with the wet exudate steam, with subsequent rectification. Turpentine composition is: Alfapinen (about 50%), betapinen (25-35%), karin (20-60%).

Pinus palustris belongs to the family Pinaceae. It grows throughout the world: U.S., Mexico, Peru, France, Portugal, Spain, Greece, Scandinavia, New Zealand, Tasmania, India, China, Russia. Turpentine is widely adapted to treat skin conditions from the times of Hippocrates and Galenus. For many centuries in China, turpentine was used for burnings, ulcers and dermatitis. The pine resin has antioxidant and antiseptic properties. It heals, excessive callusing delays, standardizing the exchange and trophic processes into the skin. Various forms of the pine tree are used in homeopathy, from the dye to the thirtieth and higher than the hundredth dilution for hives and other skin diseases associated with itching. The "Psoral" cream is produced in Israel, the quality standards are the highest in the world. Israel also has a great knowledge of high technologies and its uses. All ingredients for making the creams are investigated regularly in the Israel Public Health Ministry laboratories. The cream is certified and approved by the Israel Health Ministry and has an international GMP standard.

Composition: All the cream components satisfy the requirements of the catalog CTFA (perfume, cosmetic and fragrance association), the 12th edition and the FDA (commission for the control of medicines and foodstuffs) and the European Economic Council Directive 76/768/EEC and thus correspond to the standards of international law.

The cream "Psoral" contains the following ingredients according to the author's patented formula:

Pine Oil, pine oil, turpentine based - pine tree resin of Pinus palustris. 
Pyridoxine HCl, pyridoxine hydrochloride, vitamin B 1. 
Tocopheryl Acetate, Tocopherol acetate, vitamin E. 
Sodium Ascorbate, sodium ascorbate, one of the forms of vitamin C. 
Niacinamide, nicotinamide, nicotinic acid, vitamin B3.
Cholecalciferol, cholecalciferol, vitamin D. 
Retinyle palmitate, retinol, vitamin A. 
Petrolatum, petrolatum, petroleum jelly vaseline.

The water of the Dead Sea is used for the production of the cream.

Action: The cream has an exclusive anti-inflammatory action, activating the protective functions of the skin. The active molecules of the cream penetrate into the intercellular space of the epidermis. It acts on nerve receptors contributing to the physiological production of opiates-endorphins, and reducing feelings of sickliness and itching. Deeper penetration of the cream occurs under the effect of lipases. In this case the capillary network expands, improving microcirculation, which leads to normalization of skin sebum excretion. During the use of the “Psoral” cream the excessive callusing is delayed, normalizing metabolic and trophic processes of the skin. Antiallergic action of the creams is caused by decreasing the histamine synthesis and other biologically active materials in the centers of allergy.

The clinical trial of “Psoral” cream was conducted on volunteers (protocol № 1368), in the laboratory, "Bio Anti Aging"(Herzliya, Israel). All procedures were performed in accordance with the requirements of FDA (21 CFR 50, 56, 312) ICH-GCP, affirmative principles dated May 9, 1997, Federal Register and in accordance with standard operating procedures of the laboratory "Bio Anti Aging ".

The purpose of this study was confirming the efficacy of “Psoral” cream on affected by psoriasis skin.

Outline of the survey: This survey is an anonymous trial of “Psoral” cream in living organisms. “Psoral“ cream in its pure form was proposed to participants of a random sample.

Study periods: total duration - 5 weeks. A study was conducted from October 8, 2008 until December 17, 2008. All the patients received an informed agreement to participate in the study.

The material for the test consisted in two preparations:

  1. The cream Psoral - designed for skin affected by psoriasis, eczema, neurodermatitis, pruritus, atopic dermatitis and exudative catarrhal diathesis.
  2. Placebo cream (Vaseline).

Volunteers selection: All patients were diagnosed with psoriasis in various degrees: from insignificant local affectations to widespread disease manifestations. 

Conditions for participation in the study: The study involved 36 patients. Among them: 15 women and 21 men. Ages: ranging from18 to 56 years. After the first visit three people didn´t assist to subsequent studies. Thus only 33 patients completed the study. All those persons didn’t have serious illnesses (cardiovascular, pulmonary, nephritic, etc.) before or after the moment of the clinical trial. All women used non-hormonal methods of contraception. The renunciation to the use of antimicrobial preparations or anti-bacterial topical (shampoo, soap) and the refraining from excessive stay in the sun were recommended to all the persons during the study.

Procedure of the Study: The “Psoral” cream and “Psoral” placebo cream (Vaseline) was applied daily for 14 days, twice a day. In the first two weeks the placebo cream was applied. After then, there was a break for a week. Then, for two weeks, Psoral cream was applied. During each visit under the study, each affected section was observed before application of the drugs looking for the presence of manifestations of skin redness, peeled or lacerations, rash, irritation, etc,. The results of using the creams Placebo and Psoral are represented in the table 1 and 2. The assessment of eruptions took place as follows:

  1. - No eruptions.
  2. - Minimum eruption.
  3. - Moderate eruption.
  4. - Severe rash.

Table 1: Results of using the Placebo cream 

Patient ID number Day 1 Day 7 Day 14
№ 01 3 3 3
№ 02 3 3 3
№ 03 3 3 3
№ 04 3 3 3
№ 05 withdraw
№ 06 3 3 3
№ 07 3 3 3
№ 08 3 3 3
№ 09 3 2 2
№ 10 3 3 3
№ 11 3 3 3
№ 12 2 1 1
№ 13 3 3 3
№ 14 withdraw
№ 15 3 3 3
№ 16 withdraw
№ 17 3 3 3
№ 18 3 3 3
№ 19 2 2 1
№ 20 3 2 2
№ 21 3 3 3
№ 22 2 2 2
№ 23 2 2 2
№ 24 3 3 2
№ 25 2 2 2
№ 26 2 2 2
№ 27 2 2 2
№ 28 2 2 2
№ 29 3 3 3
№ 30 2 2 2
№ 31 3 3 3
№ 32 3 3 3
№ 33 3 3 3
№ 34 3 3 3
№ 35 2 2 2
№ 36 3 2 2

 

Table 2: The results of using Psoral cream  

 

Patient ID number Day 1 Day 7 Day 14
№ 01 3 1 0
№ 02 3 1 0
№ 03 3 1 0
№ 04 3 1 0
№ 05 withdraw
№ 06 3 1 0
№ 07 3 0 0
№ 08 3 1 0
№ 09 3 2 1
№ 10 3 2 0
№ 11 3 1 0
№ 12 2 1 1
№ 13 3 0 0
№ 14 withdraw
№ 15 3 1 0
№ 16 withdraw
№ 17 3 2 1
№ 18 3 1 0
№ 19 2 1 0
№ 20 3 1 0
№ 21 3 1 0
№ 22 2 1 0
№ 23 2 1 0
№ 24 3 2 1
№ 25 2 1 0
№ 26 2 1 0
№ 27 2 1 0
№ 28 2 1 0
№ 29 3 2 1
№ 30 2 1 0
№ 31 3 1 0
№ 32 3 1 0
№ 33 3 1 0
№ 34 3 1 0
№ 35 2 1 0
№ 36 3 1 0

 

Results: With the use of "Placebo" ointment, positive dynamics of the eruptions in patients was not practically observed. While during the use of "Psoral" cream, a significant eruption relief was observed in a 7 to 14 days period. The clinical use showed that the "Psoral" cream gives positive and noticeable improvement in skin conditions. It works not only in psoriasis, but in eczema, neurodermatitis, pruritus, atopic dermatitis and others in course, in 24 to 48 hours after the first use.

Side reactions: Side effects were not observed in any case when applying the "Psoral" cream. 

Supportability: Cream is supported well. It doesn’t create addiction.


In January 2009 we received a test lot of “Psoral” cream in Ukraine and we use it on our patients. In total Psoral cream was received by 18 patients with psoriasis, eczema, neurodermatitis, pruritus, atopic dermatitis, exudative catarrhal diathesis. We received a positive reference on the cream from all patients. The cream was mandatory prescribed together with homeopathic monotherapy as a remedy for steroid creams suspension and in order to relieve the skin itching, in the first stage of treatment. We present several observation stories.

 

Story № 1

Dima S. Child, 3 years. Suffer atopic dermatitis. The rash first appeared in his feet, in one month. At 1 year and 6 months, the rash spreads throughout his entire body. Antihistamine preparations, sorbents, and probiotikos were repeatedly given to the child. Various ointments with corticosteroids were applied by his mother constantly in these two years. Then, she went to the homeopath with his son. He had a strong itching on the night, rash on arms and legs: papule with peeling and wetting, scratching causing injuries, many traces of the previous whitish eruption and noise stroke systolic noise. 

Doctors examines: AST (aspartate transaminaza-n. Of T) - is increased by 45.1 (37), albumins in the blood are increased in 53.5 (51). Ig E (immunoglobulin-n of Trad) - is increased to 73 (to 60). TTE (transthoracic n T) - two additional chords in the left ventricular cavity. 

Diagnosis: Atopic Dermatitis, Liver disease. 

Requirements: Chelidonium 6 CH in 1 grain daily. The renunciation on the use of steroid ointments was recommended to him. He used the "Psoral" cream 1-2 times a day, if there were not a strong itching. After 1 month with this psoriasis treatment the rash was considerably better. Chelidonium 6 CH 1 grain was given to him in alternate days. After another month he had a standard result on his liver test. The rash faded, and it didn’t itch anymore. In the use of the "Psoral" cream in the second month of treatment, the need appeared 3 times, when after a violation of the diet was observed a skin night itching without changing his aspect. 6 months Catamnesis. 

Story № 2 

O. Female, 37 years. She complained about a skin rash on her hands.  Her skin palms were hard and dry and her heels have several cracks and they were wet. The eruptions tended to get worse on cold seasons. At night, she used to apply the hormone ointment in the itching area. The rash appeared when she was 29 years old. Eruptions: the look of the affected area was similar to herpes. In order to reduce itching, she poured over hot water on the eruption area. 

Diagnosis: Atopic Dermatitis. 

Designations: Rhus of thox of 30 CH 1 grain-dissolved in 200 ml water. She must consume 1 drop on alternated days and "Psoral" cream 2 times a day. After two months on this psoriasis treatment: her skin was better. She continues the treatment. After another month: her skin was totally fine. Then she stopped using Rhus and "Psoral" cream. She had an operation because of her gynecologist insistence. Doctors remove the dermoid cyst, which she had since childhood. After the operation the patient received dexamethasone, antibiotics, and flyoukonazol. Thus the rash on her hands strengthened again. Her palms became dry, cracked and itchy. She starts to receive Regividon. Then, her right ovary was removed completely. 

Requirements: Sepia 30 CH 1 grain dissolved in 100 ml of water, 1 tablespoon of tea, 2 times a week, and "Psoral" cream 2 times a day. After 2 months her skin was better. Then she stared to take regividon again and consequently she lost her menstruation. She had some fluids in the evening, she couldn’t sleep, and she felt very badly in the morning. Also she had many fluids with heat and no sweating at all. Requirements: Crocus 30CH in 3 grains daily, "Psoral" cream 2 times a day. After 2 more months her skin did not itch, new eruptions did not appeared. She lost her menstruation again. The fluids became normally. It was recommended her to continue the treatment as before. The patient was very happy about the fact that the itching and rashes no longer could bother her, so she was able to refuse steroid ointments. Still, observation continues.

Story № 3

Man v., 47. He complained about skin rash on his elbows, knees, toes and calves. He manifested dryness of his skin, several cracks, itching, wetting, rash - deep red platelets with peeling (desquamation) and itching during the day. 

Diagnosis: psoriasis. The patient is talkative and sociable. He sleeps covering himself with a sheet. He had a huge appetite. He had been using celestoderm for 4 years. In the last year he used it every day. 

Doctors examines: ALT (alanine aminotransferase also called alanine transaminase (ALT)-N Tr) -118.5 (41), GGT (gamma glutamyl-n tr) - 1320 (61). In an U.S. (ultrasound) they found liver hemangioma. 

Requirements: 200 CH 1 grain Phosphor dissolved in 200 ml of water, to consume 1 tea spoon once a week, and  to apply “Psoral” cream 2 times a day. After 1.5 months without using celestoderm Psoriasis began to disappear. In general, the patient was healthy and he continued the treatment. After 3 months, psoriasis platelets on his hands were normal. After 2 months using the same treatment, he was healthy and his skin was normal. Then, he continued with the treatment, without using steroid ointments. Finally, he used “Psoral” cream very rarely.


Now, having a little experience on psoriasis treatment using Psoral cream, we want to share some details of its use. The cream must be applied non-abundantly, one or two times a day in rashes or areas under the bandage, with, at least, 6 hours between applications. You can use the cream over the skin throughout the entire body, including the scalp. You can use this cream for an unlimited time. However, the best way of using the cream is continuously for 15-20 days and then sporadically as ordered. During the year, the utilization cycle of the cream from 15-20 days, can be repeated from 2 to 6 times and more in the case that you needed. You must use the creams until complete recovery of the skin, but no more than 2 weeks. The cream can be used in children older than 3 months and pregnant women without sensitivity to individual components of the cream.

Notes: The odorless of the cream is from a specific conifer. Do not use the cream, if you have previously reaction to the substances of its composition. Do not allow entry into your eyes. In an accidental admission, eyes must be flushed in a large amount of water. If allergic reactions were observed during the use of the cream, stop using it. You can not apply the cream on open wounds, scratches, peeling, sections with sensitive thin skin (eg, under the eyes and in the perineum) and mucous membranes. Do not allow the cream to be eaten by children or animals. The cream is only for external use.

“Psoral cream” can stain clothing. Keep the cream in a cool dark place. The cream cannot be exposed to direct sunlight. Keep the cream in inaccessible places for children and animals. The main characteristic of the “Psoral” cream is its natural composition. It is highly effective and absolutely safe. Because of “Psoral” cream you can stop using corticosteroids creams, even when you have used them for a long period of time. Clinical investigations showed that the cream gives positive results and palpable improvement for skin diseases such as psoriasis, eczema, neurodermatitis, pruritus, atopic dermatitis and others in a course of 24-48 hours after the first application.